Anti-M protein

Anti-M protein, Recombinant, IgG kappa, Rabbit
SKU
ABAAb03920-23.0
Packaging Unit
100 μg
Manufacturer
Absolute Antibody

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CloneID: 49.8.9

Antigen Long Description: The original antibody was generated by immunizing BALB/c BYJ mice with streptococcal M type 5 membranes followed by a second, boosting dose of M type 5 streptococcal membranes.

Origin Pub PMID: 11282394

Buffer Composition: PBS with 0.02% Proclin 300.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Uniprot Accession No.: P02977

Specificity Statement: This antibody reacts with α-helical molecules and the carbohydrate N-acetyl-b-D-glucosamine (GlcNac). Specifically, it binds streptococcal M-protein (type 5), human myosin, keratin, DNA, vimentin, troponin, ganglioside, and glycophorin M,N.

Application Notes (Clone): This antibody reacts with human heart cells and whole streptococci (group A, M type 5), as shown in an ELISA, and with human heart cells, human sarcolemma (weak response), and group A streptococcal membranes (weak response), as shown in a WB (Cunnigham et al., 1984; PMID: 6384047). This antibody labels the cytoplasm of epidermal cells and epidermal appendages in normal and psoriatic skin, as shown by immunofluorescent staining (Swerlick et al., 1986; PMID: 3525693). This antibody binds CV (B3), as shown in an ELISA; neutralizes PV-1 and CV (B3), as shown in a plaque-reduction neutralization assay; and is slightly cytotoxic to rat fibroblasts, as shown in a cytotoxicity assay (Cunningham et al., 1992; PMID: 1311095). This antibody reacts with retinal S-antigen (S-Ag), as shown in an ELISA (Lerner et al., 1995; PMID: 8722579). This antibody binds myosin at a medium relative avidity, as determined in a competitive ELISA. Reactivity with glycophorin M and N was determined by hemagglutination assay (Mertens et al., 2000; PMID: 11282394).
More Information
SKU ABAAb03920-23.0
Manufacturer Absolute Antibody
Manufacturer SKU Ab03920-23.0
Package Unit 100 μg
Quantity Unit STK
Reactivity Human, Rat (Rattus), Various species
Clonality Recombinant
Application Western Blotting, ELISA, Hemagglutination Inhibition
Isotype IgG kappa
Host Rabbit
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