Anti-MAdCAM-1 (MECA-89)

Anti-MAdCAM-1 [MECA-89], Recombinant, IgG kappa, Rabbit

CloneID: MECA-89

Antigen Long Description: Endothelial cells isolated from BALB/c mouse mesenteric and peripheral lymph nodes.

Buffer Composition: PBS only.

Specificity Statement: The antibody is specific for mouse MAdCAM-1. The antibody recognizes the second immunoglobulin domain, interfering with L-selectin interactions of MAdCAM-1. The mucosal lymphocyte homing receptor MAdCAM-1 is expressed in the high endothelial venules of the mesenteric lymph nodes (MLN) and Peyer's patches (PP) and in the flat epithelium of the lamina propria (LP).

Application Notes (Clone): The antibody bound to the second domain of MAdCAM-1 and did not block MAdCAM-1-dependent binding in vitro (Streeter et al., 1988; PMID:3340147). The antibody was used for immunohistochemical analysis of healthy AKR control mice and it showed faint basal expression of MAdCAM-1 in the terminal ileum (Bachmann et al. 2006). The antibody blocked interactions with L-selectin in vivo (Bargatze et al., 1995; PMID: 7542550).

• SKU: ABAAb03850-23.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03850-23.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Mouse (Murine)
• Clonality: Recombinant
• Application: Immunohistochemistry, Blocking
• Isotype: IgG kappa
• Host: Rabbit