CloneID: 12F3A4C11
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing mice with MPO.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P05164
Specificity Statement: The antibody is specific for MPO. Myeloperoxidase (MP0) is a cationic glycoprotein with a relative molecular weight of 133-155kD and an isoelectric point of 1.0 secreted by neutrophils, macrophages and monocytes. MPO is part of the host defense system of polymorphonuclear leukocytes and it is responsible for microbicidal activity against a wide range of organisms.
Application Notes (Clone): The antibody specifically detected MPO by Western blot analysis. The antibody 12F3A4C11 and a commercial rabbit polyclonal antibody were used to stain granulocytic sarcoma. Results showed the antibody specificity is comparable to the commercial antibody. Further, the sensitivity of the antibody 12F3A4C11 was higher than the commercial antibody. The antibody and the commercially available antibody were simultaneously detected on the normal tissue chip, indicating that the specificity of the antibody in normal tissue was equivalent to that of the commercially available antibody (CN112194724B).
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