CloneID: 1-10
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by introducing site directed mutations in CDRs of the parental mouse antibody.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P16860
Specificity Statement: This antibody binds NT-proB-type natriuretic peptide (NT-proBNP), a 76 amino acid cleaved N-terminal (NT)-pro hormone BNP (NT-proBNP), which is a non-active prohormone that is released from the protein proBNP. BNP is a naturally secreted cardiac regulatory hormone that influences blood pressure and vascular water retention in human physiology. The plasma BNP and NT-proBNP concentration are clinically recognized biomarkers for various cardiovascular diseases.
Application Notes (Clone): The original mouse IgG antibody binds human NT-proBNP with a binding affinity of Kd= 1.6 X 10^(-10) M. This antibody can be used for the detection of NT-proBNP in a sample using ELISA (CN113004405).
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