CloneID: 6A9
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing mice against a 72-kilodalton (kDa) P-cadherin fragment from A-431 cells.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P22223
Specificity Statement: The antibody is specific for P-Cadherin-1 (CDH3). P-Cadherin-1 is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail.
Application Notes (Clone): The antibody detected human P-Cadherin from A431 cell lysate by Western blot analysis. The antibody was used to immunoprecipitate P-Cadherin. Further, the antibody was shown to have inhibitory activity, by disrupting P-cadherin-mediated cell-cell adhesion with A-431 cells (Lewis et al., 1994; PMID: 8006450). The antibody detected P-cadherin by immunofluorescence (Owens et al., 2000; PMID: 10708559).
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