Anti-paraoxon (organophosphate) (A.17 L47K)

Anti-paraoxon (organophosphate) [A.17 L47K], Recombinant, IgG kappa, Rabbit

CloneID: A.17 L47K

Antigen Long Description: The original antibody was generated via phage display from the Griffin.1 library by panning against reactive phosphonate ester 1.

Origin Pub PMID: 32859757

Buffer Composition: PBS with 0.02% Proclin 300.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Specificity Statement: This antibody is specific for paraoxon.

Application Notes (Clone): This antibody is a covalent trap for Paraoxon and other organophosphate substrates, catalyzing the hydrolysis reaction through the S_N2 mechanism. The catalytic parameters of this antibody were measured, and its K_D was found to be 170 ± 8 μM; it exhibited a 340-fold reactivity enhancement for paraoxon relative to wild-type Ig-paraoxonase. Furthermore, its crystal structure in complex with paraoxon was determined (Mokrushina et al., 2020; PMID: 32859757).

• SKU: ABAAb04213-23.0
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab04213-23.0
• Package Unit: 100 μg
• Quantity Unit: STK
• Reactivity: Various species
• Clonality: Recombinant
• Isotype: IgG kappa
• Host: Rabbit