Anti-PD-1 (Anti-human PD-1 antibody)

Anti-PD-1 [Anti-human PD-1 antibody], Recombinant, IgG1 kappa, Mouse

CloneID: Anti-human PD-1 antibody

Antigen Long Description: The original antibody was generated by immunizing transgenic mice with PD-1.

Buffer Composition: PBS only.

Uniprot Accession No.: Q15116

Specificity Statement: The antibody is specific for PD-1. The antibody binds the extracellular region of the human PD-1 protein receptor. PD-1 is a type I membrane protein with 288 amino acids, and is one of the main known immune checkpoints. PD-1 is expressed in activated T lymphocytes, and it binds ligands PD-L1 and PD-L2.

Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis (EC50 = 76 pM). The antibody blocked the binding between PD-1 protein and its ligands PD-L1 and PD-L2 by the receptor ligand binding assay of PD-1 protein. Lymphocyte stimulation assay detected that PD-1 antibody blocked the binding of PD-1 protein to its ligands PD-L1 and PD-L2, thereby releasing its inhibition of T lymphocyte activity (CN106928361A).

• SKU: ABAAb03804-1.1-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03804-1.1-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: ELISA, Blocking, Inhibition
• Isotype: IgG1 kappa
• Host: Mouse