CloneID: mAb3D3
Antigen Long Description: The original antibody was generated by immunizing BALB/C mice with purified human podocalyxin-glutathione S-transferase (GST) fusion protein containing the intracellular, transmembrane, and a part of the extracellular domain of human PCLP.
Buffer Composition: PBS only.
Uniprot Accession No.: O00592
Specificity Statement: The antibody is specific for human podocalyxin. The epitope recognized by the antibody is located on the extracellular domain of podocalyxin. Podocalyxin, a sialoglycoprotein, is thought to be the major constituent of the glycocalyx of podocytes in the glomerulus (Bowman's capsule) in the kidneys. It is a member of the CD34 family of transmembrane sialomucins.
Application Notes (Clone): The antibody recognized rabbit PCLP1 in human renal cortical sections on immunofluorescence. The antibody detected PCLP by western blot analysis (Kershaw et al., 1997; PMID: 9188463). The antibody detected PCLP in HEV of tonsil by immunofluorescence analysis. The antibody immunoprecipitated PCLP from colon carcinoma cell lysate (Thomas et al., 2009; PMID: 19118161).
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