CloneID: POmAb
Heavy Chain modification: Fc Silent™
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P00734
Specificity Statement: The antibody is specific for the open form of prothrombin. Its epitope is located in kringle-1, comprising an extended binding interface centered at residues R90-Y93.
Application Notes (Clone): The binding affinity of original format of the antibody to prothrombin was measured by surface plasmon resonance. The crystal structure of the Fab fragment of the antibody was determined. The antibody could prolong phospholipid-initiated and diluted Russell viper venom clotting time (Kumar et al., 2024; PMID: 38437497).
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