CloneID: 334MXX
Antigen Long Description: The original antibody was generated by immunizing mice with human PVRIG linked to a human IgG Fc region.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q6DKI7
Specificity Statement: The antibody specifically binds to human PVRIG.
Application Notes (Clone): The original version and the humanized version antibody were able to inhibit PVRIG activity and signaling. The binding of the original format or the humanized version of the antibody to PVRIG decreased PVRL2 activity, as shown by FACS analysis on HEK-293T cells transfected with hPVRIG (WO2018017864A3).