Anti-RANK-L (WBP114_5.20)

Anti-RANK-L [WBP114_5.20], Recombinant, IgG1 kappa, Human

CloneID: WBP114_5.20

Antigen Long Description: The original antibody was generated by immunizing Balb/c mice with human RankL protein.

Buffer Composition: PBS only.

Uniprot Accession No.: O14788

Specificity Statement: The antibody is specific for human-RANK-L. The antibody cross reacts with murine RANKL. RANKL is a tumor necrosis factor related protein that binds to, and activates, the TNF receptor related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differentiation and activation during normal bone remodeling and during disease

Application Notes (Clone): The specificity of the original format of the antibody to human and mouse RANKL was confirmed by ELISA analysis (EC50= 0.26 nM and 0.067 nM, respectively). The antibody could block the RANKL binding to RANK (IC50 = 2.23 nM). The original format of the antibody could inhibit the RANKL-inducible luciferase activity (IC50 = 3.31 nM). The binding affinity of the original format of the antibody to RANKL was measured by surface plasmon resonance (Kd= 0.7 nM) (WO2019080909).

• SKU: ABAAb04162-10.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab04162-10.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: ELISA, Super-Resolution Microscopy, Inhibition
• Isotype: IgG1 kappa
• Host: Human