Anti-ROR1 (M508)

Anti-ROR1 [M508], Recombinant, IgG1 kappa, Human

CloneID: M508

Antigen Long Description: The original antibody was generated by immunizing wild-type mice with full-length extracellular portion of human ROR1 protein.

Buffer Composition: PBS only.

Uniprot Accession No.: Q01973

Specificity Statement: This antibody binds the human ROR1. ROR1 is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. It is a pseudo kinase that lacks catalytic activity. Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes.

Application Notes (Clone): The binding reactivity of this antibody to full-length extracellular portion of human ROR1 protein and its truncated forms was done using ELISA. The binding reactivity and specificity of this antibody was comparable with another anti-ROR1 antibody R12. The mouse-human chimeric IgG1 version of this antibody binds human ROR1 with a binding affinity of Kd= 1.4 nM. This antibody could bind human ROR1 expressed on the surface of breast cancer cell line MDA-MB-231 in a flow cytometric assay. This antibody is recommended for detection of human ROR1 expressing tumor cells (CN114539411).

• SKU: ABAAb03863-10.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03863-10.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: ELISA, Flow Cytometry, Functional Assay
• Isotype: IgG1 kappa
• Host: Human