Anti-RSPO2 (h130M23-H1L2)

Anti-RSPO2 [h130M23-H1L2], Recombinant, IgG1 kappa, Mouse

CloneID: h130M23-H1L2

Antigen Long Description: The antibody is the humanized version of the murine 130M23.

Buffer Composition: PBS only.

Uniprot Accession No.: Q6UXX9

Specificity Statement: The antibody specifically reacts with human and mouse RSPO2.

Application Notes (Clone): The antibody was shown to completely block β-catenin signaling, demonstrating it is a specific inhibitor of RSPO2. The antibody blocked soluble RSPO2 binding to LGR5. The antibody had a binding affinity for human RSPO2 of 0.14 nM and mouse RSPO2 of 0.35 nM. The antibody demonstrated strong anti-tumor growth activity in combination with gemcitabine in a pancreatic xenograft model and inhibition of pancreatic tumor growth in vivo as a single agent and in combination with additional therapeutic agents. The humanized version of the antibody was produced. The humanized version had a binding affinity for human RSPO2 of 0.13 nM (US8802097B2).

• SKU: ABAAb03958-1.1-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03958-1.1-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine)
• Clonality: Recombinant
• Application: Blocking, Super-Resolution Microscopy, In Vivo Assay
• Isotype: IgG1 kappa
• Host: Mouse