CloneID: h130M23-H1L2
Heavy Chain modification: Fc Silent™
Antigen Long Description: The antibody is the humanized version of the murine 130M23.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: Q6UXX9
Specificity Statement: The antibody specifically reacts with human and mouse RSPO2.
Application Notes (Clone): The antibody was shown to completely block β-catenin signaling, demonstrating it is a specific inhibitor of RSPO2. The antibody blocked soluble RSPO2 binding to LGR5. The antibody had a binding affinity for human RSPO2 of 0.14 nM and mouse RSPO2 of 0.35 nM. The antibody demonstrated strong anti-tumor growth activity in combination with gemcitabine in a pancreatic xenograft model and inhibition of pancreatic tumor growth in vivo as a single agent and in combination with additional therapeutic agents. The humanized version of the antibody was produced. The humanized version had a binding affinity for human RSPO2 of 0.13 nM (US8802097B2).
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