CloneID: Siglec7-01
Antigen Long Description: The original antibody was isolated from a human Fab antibody library by panning against human siglec-7.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q9Y286
Specificity Statement: This antibody binds human siglec-7. It is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid.
Application Notes (Clone): This antibody can bind recombinant human siglec-7 protein in an ELISA and western blot. The binding affinity of the IgG antibody for human siglec-7 was reported to be Kd= 71.5 nM. In vitro, this antibody was capable of enhancing killing effect of NK cells on tumor cells (CN106831989).
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