CloneID: 591-37-M1
Antigen Long Description: The original antibody was raised by immunizing mice with Trx-bhSOD1-A4V.
Buffer Composition: PBS only.
Specificity Statement: This antibody is specific for misfolded SOD1.
Application Notes (Clone): This antibody was used for an ELISA on b-hSOD1, b-hSOD1-A4V, b-hSOD1-G85R and b-hSOD1-G93A. This antibody was used for immunoprecipitation on HEK-293T cells transfected with mutated human SOD1. The antibody was used for immunofluorescence on HEK-293T cells transiently transfected with hSOD1-G93A. The antibody was also used for immunohistochemistry on tissue from a mouse model of ALS, and on spinal cords of sporadic ALS patients, the mice expressed either hSOD1 or hSOD1-G93A. This antibody was used in vivo on mouse ALS models. It showed that the mice treated with the antibody maintained better weight and extended life (US9663586B2).
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