Anti-TIGIT (1F4)

Anti-TIGIT [1F4], Recombinant, IgG1 kappa, Human

CloneID: 1F4

Heavy Chain modification: Fc Silent™

Antigen Long Description: The original antibody was generated by immunizing hamsters with murine TIGIT-Fc fusion protein.

Buffer Composition: PBS only.

Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.

Uniprot Accession No.: Q495A1

Specificity Statement: The antibody is specific for human TIGIT. TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

• SKU: ABAAb03858-10.3-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03858-10.3-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine)
• Clonality: Recombinant
• Isotype: IgG1 kappa
• Host: Human