CloneID: L3C
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing Balb/c mice with human TIM-3.
Buffer Composition: PBS only.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques.
Uniprot Accession No.: Q8TDQ0
Specificity Statement: This antibody binds human TIM-3. Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein expressed on the cell surface of IFNγ producing CD4+ Th1 and CD8+ Tc1 cells. This protein is also expressed on the surface of Th17 cells, regulatory T-cells and innate immune cells like dendritic cells, NK cells and monocytes. It is a cell surface receptor implicated in modulating innate and adaptive immune responses.
Application Notes (Clone): This antibody can be used in the detection of human TIM-3 from plasma of patients using sandwich ELISA. The recombinant human rhGal-9 protein was used to capture TIM-3 and this antibody was used as a detecting antibody. The detection sensitivity of this antibody for TIM-3 was 1ng/ml (CN103665164).
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