CloneID: B1A1
Antigen Long Description: The original antibody was isolated by panning a phage display library against VEGFR2.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P35968
Specificity Statement: The antibody is specific for VEGFR2.
Application Notes (Clone): The bispecific antibody (A1-A8)-LALA associated with either VEGFR2 or PDLl fast and stayed on either VEGFR2 or PDLl long (KD values of BsAb (A1-A8) were about 200 pM and 3.2 pM for the hVEGFR2 and hPDLl). A cytokine secretion assay was carried out with the bispecific antibody and B1A1. The results indicate that in the present of BsAb (A1-A8)-LALA, the secretion of cytokine IL2 and INFy in PBMC when stimulated by SEB was higher than the control antibody B1A1, demonstrating that BsAb (A1-A8)-LALA retains the potency of its parental antibody B1A1 (against VEGFR2) and dsD7A8-LALA (against PDL1) (EP3411068A4).
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