CloneID: RV203
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing a BALB/c mouse with a cytoskeletal vimentin extract of calf lens.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P08670
Specificity Statement: The antibody reacts exclusively with vimentin, which is expressed in mesenchymal cells and mesenchymal derived tumors e.g. lymphoma, sarcoma and melanoma.
Application Notes (Clone): The antibody detected vimentin on cytoskeletal extracts of bovine lens, BHK-21 and HeLa cells by western blot analysis. The antibody detected vimentin on connective tissue fibroblasts of hamster tongue, polygonal BHK-21/C13 cells and elongated BHK-21 cells by immunohistochemistry (Schaart et al., 1991; PMID: 2065865).
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