CloneID: scFv 96
Heavy Chain modification: Fc Silent™
Antigen Long Description: This antibody was raised by first immunizing twelve-week old white Leghorn hens intramuscularly with CPV-VLP. A library was then constructed from these chickens and panned against CPV-VLP.
Buffer Composition: PBS only.
Chimeric Use Statement: This full-length, chimeric mouse antibody was made using the variable domain sequences of the original Chicken scFv format, for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P61826
Specificity Statement: This antibody is specific for the VP2 for the Canine Parvovirus. VP2 is a capsid protein that self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The Canine Parvovirus is a disease mainly affecting dogs with a 91% mortality rate.
Application Notes (Clone): To analyse the sensitivity of the scFv version of this antibody an ELISA was performed on CPV-VP2. Furthermore, the ability of this antibody to prevent a CPV infection was determined, it showed a decrease of 30% over 72 hours (Ge et al, 2020; pmid:32883344).
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