Description: Adenomatous Polyposis Coli (APC) is a protein with many cellular functions. It is a tumor suppressor and negative regulator of Wnt signaling. APC has roles in cell adhesion and cell migration. Mutations in APC are assuciated with several diseases. The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product origin: Animal - Mus musculus (mouse)
Conjugate: Purified, BSA-free
Concentration: 1 mg/mL
Storage buffer: PBS, no BSA, no azide
Clone: ALi 12-28
Immunogen: Recombinant fragment of human APC protein (around aa 1-433)
Antibody Reactivity: Adenomatous Polyposis Coli
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- PNAS USA (1998) 95:3122-3127. (WB, IF, epitope mapping)
- EMBO Rep (2005) 6:184-190. (IF)
- BMC Cell Biol (2006) 7: 3. (IF, WB)
- Int J Mol Med (2008) 21:19-31. (IHC, frozen)
- J Biol Chem (2012) 287(34): 28552-28563. (IP, WB)
Entrez Gene ID: 324
Expected AB Applications: IHC (frozen) (published for clone)/IF (published for clone)/IP (published for clone)/WB (published for clone)
Z-Antibody Applications: IF (published)/IHC, frozen (published)/IP (published)/WB (published)
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