Product Description: Asterric acid is an antibiotic fungal metabolite that completely inhibits the binding of the potent vasoconstrictor endothelin (ET)-1 to the ETA receptor in A10 cells at 0.1 μM.1 Asterric acid derivatives have also been shown to inhibit VEGF-induced tube formation of human umbilical vein endothelial cells at 3-10 μM, which suggests its usefulness as an antiangiogenic agent.
Applications: COVID-19-immunoregulation
Formula: C17H16O8
References: [1]Ohashi, et al. Asterric acid, a new endothelin binding inhibitor. J. Antibiot. (Tokyo) 45, 1684-1685 (1992).
CAS Number: 577-64-0
Molecular Weight: 348.30
Research Area: Infection
Target: Antibiotic