Conjugation: HRP: Horseradish Peroxidase
Description of Target: Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12-ATG5 conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A), a homolog of yeast Apg8, to a membrane-bound form.Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM].
Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ATG10
Key Reference: Criollo,A., (2007) Cell Death Differ. 14 (5), 1029-1039
Molecular Weight: 25kDa
Peptide Sequence: Synthetic peptide located within the following region:
TPVLKNSQKINKNVNYITSWLSIVGPVVGLNLPLSYAKATSQDERNVPProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Ubiquitin-like-conjugating enzyme ATG10
Protein Size: 220
Purification: Affinity Purified
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