Product Description: Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids[1][2][3].
Applications: Cancer-programmed cell death
Formula: C40H69N5O7
References: [1]MADDON Paul J, et al. PSMA ANTIBODIES AND PROTEIN MULTIMER. 2002 October 23. WO 03/034903 A2/[2]Peter D. Senter, et al. PENTAPEPTIDE COMPOUNDS AND USES RELATED THERETO. 2005 Jan. 13. US 2005/0009751 A l./[3]LAW, Che-Leung, et al. TREATMENT OF IMMUNOLOGICAL DISORDERS 5 USING ANTI-CD30 ANTIBODIES. 2002 November 20. WO 03/043583 A2.
CAS Number: 160800-57-7
Molecular Weight: 732.01
Compound Purity: 99.89
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: ADC Cytotoxin;Microtubule/Tubulin
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