Auristatin F, CAS 163768-50-1

Product Description: Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) [1][2].

Applications: Cancer-programmed cell death

Formula: C40H67N5O8

References: [1]Roy S, et al. SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth. Chem Commun (Camb). 2017 Apr 11;53(30):4234-4237./[2]Park MH, et, al. Pharmacokinetic and Metabolism Studies of Monomethyl Auristatin F via Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry. Molecules. 2019 Jul 29;24(15):2754.

CAS Number: 163768-50-1

Molecular Weight: 745.99

Compound Purity: 99.58

Research Area: Cancer

Solubility: DMSO : 200 mg/mL (ultrasonic)

Target: ADC Cytotoxin;Microtubule/Tubulin

• SKU: MEXHY-15583-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-15583-100
• Package Unit: 100 mg
• Quantity Unit: STK