Product Description: AZD5904 is a selective and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.
Applications: Neuroscience-Neuromodulation
Formula: C10H12N4O2S
References: [1]Myeloperoxidase (MPO) inhibitor./[2]Tidén AK, Sjögren T, Svensson M, et al. 2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation. J Biol Chem. 2011;286(43):37578-37589. /[3]Chai W, Aylor K, Liu Z, Gan LM, Michaëlsson E, Barrett E. Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance. Am J Physiol Endocrinol Metab. 2019;317(6):E1063-E1069. /[4]Ramachandra CJA, Kp MMJ, Chua J, et al. Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes. Cardiovasc Res. 2022;118(2):517-530.
CAS Number: 618913-30-7
Molecular Weight: 252.30
Compound Purity: 99.93
Research Area: Neurological Disease
Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Glutathione Peroxidase
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