B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF740 conjugate, 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF740 conjugate, 0.1mg/mL
SKU
BTMBNC742652-500
Packaging Unit
500 uL
Manufacturer
Biotium

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Description: B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Origin: Animal - Oryctolagus cuniculus (domestic rabbit), Bos taurus (bovine)

Conjugate: CF740

Concentration: 0.1 mg/mL

Storage buffer: PBS, 0.1% rBSA, 0.05% azide

Clone: B7H4/2652R

Immunogen: Recombinant human B7-H4 protein fragment (exact sequence is proprietary)

Antibody Reactivity: B7-H4

Entrez Gene ID: 79679

Z-Antibody Applications: Flow (verified)/IF (verified)/IHC, FFPE (verified)

Verified AB Applications: Flow (verified)/IF (verified)/IHC (FFPE) (verified)

Antibody Application Notes: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/ELISA: 2-4 ug/m for coating order Ab without BSA/Immunohistology (formalin): 1-2 ug/mL for 30 minutes at RT/Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes/Optimal dilution for a specific application should be determined by user
More Information
SKU BTMBNC742652-500
Manufacturer Biotium
Manufacturer SKU BNC742652-500
Package Unit 500 uL
Quantity Unit STK
Reactivity Human
Clonality Recombinant
Application Immunofluorescence, Flow Cytometry, Immunohistochemistry
Isotype IgG
Host Rabbit
Conjugate Conjugated, CF740
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