Clone Name: BAP1/8959R
Light Chain: Kappa
Application Note: IHC-P: 1-2μg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Positive Control: Human breast or malignant mesothelioma
Form: Liquid
Buffer (with preservative): PBS, 0.05% BSA (Please contact us for PBS only format), 0.05% Sodium Azide.
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
Uniprot ID: Q92560
Antigen Species: Human
Immunogen: Recombinant fragment (630-729 aa) of human BAP1 protein.
Purification: Purified by Protein A/G
Conjugation: Unconjugated
Full Name: BRCA1 associated protein 1
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