Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[(1R)-2-[(cis-4-aminocyclohexyl)amino]-1-[(4-cyanophenyl)methyl]ethyl]-2-chloro-4-methoxy-5-[5-[[[(1R)-1-(4-methylphenyl)ethyl]amino]methyl]-2-furanyl]-benzamide
Purity: ≥98%
Formula Markup: C38H44ClN5O3
Formula Weight: 654.2
CAS Number: 2099142-76-2
Notes: BAY-850 is an inhibitor of the ATPase family AAA domain-containing protein 2 (ATAD2; IC50 = 22 nM in a time-resolved FRET assay using a tetra-acetylated histone H4 peptide).{40537} It is selective for ATAD2 over a panel of 32 bromodomain family proteins, including ATAD2B, a panel of 354 kinases, and a panel of 25 G protein-coupled receptors (GPCRs) at 1 µM. BAY-850 induces dimerization of ATAD2 in a concentration-dependent manner in a cell-free assay and inhibits the ATAD2-chromatin interaction in MCF-7 breast cancer cells in a fluorescence recovery after photobleaching (FRAP) assay. It induces apoptosis and cell cycle arrest in, and inhibits proliferation, invasion, and migration of, PA-1 and SKOV3 ovarian cancer cells when used at a concentration of 5 µM.{51867} BAY-850 (20 mg/kg) reduces tumor volume and the percentage of lung metastases in a SKOV3 mouse xenograft model. See the Structural Genomics Consortium (SGC) website for more information.
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