Product Description: BAY1125976 is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
Applications: Cancer-Kinase/protease
Formula: C23H21N5O
References: [1]Politz O, et al. BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. Int J Cancer. 2017 Jan 15;140(2):449-459.
CAS Number: 1402608-02-9
Molecular Weight: 383.45
Compound Purity: 99.52
Research Area: Cancer
Solubility: DMSO : 25 mg/mL (ultrasonic)
Target: Akt