BIX02188, CAS 334949-59-6

Product Description: BIX02188 is a potent MEK5-selective inhibitor with an IC50 of 4.3 nM. BIX02188 inhibits ERK5 catalytic activity, with an IC50 of 810 nM.

Applications: Cancer-Kinase/protease

Formula: C25H24N4O2

References: [1]Li L, et al. Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells. Biochem Biophys Res Commun. 2008 May 23;370(1):159-63./[2]Tatake RJ, et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5./[3]Badshah II, et al. Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. Front Pharmacol. 2014 Apr 21;5:71.

CAS Number: 334949-59-6

Molecular Weight: 412.49

Compound Purity: 99.85

Research Area: Cancer

Solubility: DMSO : ≥ 45 mg/mL

Target: ERK;MEK

• SKU: MEXHY-12055-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-12055-25
• Package Unit: 25 mg
• Quantity Unit: STK