BVT 14225, CAS 376638-65-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-N,N-diethyl-4-thiazoleacetamide

Purity: ≥98%

Formula Markup: C16H20ClN3O3S2

Formula Weight: 401.9

CAS Number: 376638-65-2

Notes: BVT 14225 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1; IC50s = 52 and 284 nM for the human and mouse enzymes, respectively).{72442} It is selective for human 11β-HSD1 over human 11β-HSD2 (IC50 = >10,000 nM). It inhibits 11β-HSD1 by 55% in HEK293 cells expressing human HSD11B1, the gene encoding 11β-HSD1, when used at a concentration of 10 µM.{72443} BVT 14225 (50 mg/kg) reduces blood glucose levels in a rat model of diabetes induced by streptozotocin (Item No. 13104) and nicotinamide (Item No. 11127).

• SKU: CAY41224-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41224-5
• Package Unit: 5 mg
• Quantity Unit: STK