Product Description: CCT036477 is a Wnt/β-catenin pathway inhibitor. CCT036477 blocks transcription at β-catenin without altering its levels. CCT036477 inhibits proliferation of various cancer cells, development of embryos, and expression of Wnt target genes (PPARδ, Cyclin D1, TCF4, and ID2)[1][2].
Formula: C21H18ClN3
References: [1]Serttas R, et al. Pretreatment of prostate cancer cells with salinomycin and Wnt inhibitor increases the efficacy of cabazitaxel by inducing apoptosis and decreasing cancer stem cells. Med Oncol. 2023 Jun 1;40(7):194./[2]Mathur R, et al. Targeting Wnt pathway in mantle cell lymphoma-initiating cells. J Hematol Oncol. 2015 Jun 6;8:63.
CAS Number: 305372-78-5
Molecular Weight: 347.84
Compound Purity: 99.42
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: CDK;PPAR;Wnt;β-catenin
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