CCT369260, CAS 2253878-44-1

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: rel-5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-2H-benzimidazol-2-one

Purity: ≥95%

Formula Markup: C24H31ClF2N6O2

Formula Weight: 509.0

CAS Number: 2253878-44-1

Notes: CCT369260 is a degrader of Bcl-6.{66847} It induces degradation of Bcl-6 in SU-DHL-4, OCI-LY1, and Karpas-422 cells with half-maximal degradation concentration (DC50) values of 0.09, 0.049, and 0.062 µM, respectively. CCT369260 inhibits the growth of SU-DHL-4, OCI-LY1, and OCI-Ly3 cancer cells (GI50s = 0.092, 0.035, and 1.6 µM, respectively). It reduces intratumoral Bcl-6 levels in an OCI-LY1 lymphoma mouse xenograft model for up to ten hours after administration of a 15 mg/kg dose.

• SKU: CAY41314-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41314-5
• Package Unit: 5 mg
• Quantity Unit: STK