Description: CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells. It induces cellular activation and helps trigger neutrophil respiratory burst. It is expressed in hairy cell leukemias, acute non-lymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: HC1/1
Immunogen: Human monocytic U937 phorbol ester-treated cells
Antibody Reactivity: CD11c
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- Hybridoma (1988) 7:2, 167-176. (IHC)
- J Exp Med (1991) 174 (6): 1313-1322. (Flow; receptor activation; IP)
Entrez Gene ID: 3687
Expected AB Applications: Flow, surface (published for clone)/Functional studies (published for clone)/IP (published for clone)
Z-Antibody Applications: Flow (verified)/Flow, surface (published)/Functional studies (published)/IP (published)
Verified AB Applications: Flow (verified)
Antibody Application Notes: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Immunofluorescence: 0.5-1 ug/mL/Flow Cytometry 0.5-1 ug/million cells/0.1 mL
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