Description: This antibody recognizes a protein of 80-90 kDa, identified as CD36. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36.
Product origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: 1A7
Immunogen: Human CD36 from platelets
Antibody Reactivity: CD36
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- Am J Pathol (1999) 155(2): 441-452. (WB)
- Am J Pathol (2003) 162(3): 771-779. (functional studies, IP)
Entrez Gene ID: 948
Expected AB Applications: Functional studies (published for clone)/IP (published for clone)/WB (published for clone)
Z-Antibody Applications: Functional studies (published)/IP (published)/WB (published)
Antibody Application Notes: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Flow cytometry: 0.5-1 ug/million cells/Functional Studies Order Ab without Azide/Immunofluorescence: 0.5-1 ug/mL/Optimal dilution for a specific application should be determined by user
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