Description: Recognizes the N-glycosylated glycoprotein of 120 kDa with intra-chain disulfide bonds, identified as CD50 or ICAM-3. CD50 is the major ligand for LFA-1 (CD11a/CD18) and may have signaling role to increase adhesion. It is expressed on thymocytes and T lymphocytes and is resistant to treatment with phosphatidylinositol (PI) phospholipase C.
Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: ICO-60
Immunogen: Human ICAM3
Antibody Reactivity: CD50
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- J Gen Virol (1995) 76: 1345-1352. (functional assay)
- JBC (1996) 271(39): 23920-23927. (Flow, functional assay)
Entrez Gene ID: 3385
Expected AB Applications: Flow, surface (published for clone)/Functional studies (published for clone)
Z-Antibody Applications: Flow, surface (published)/Functional studies (published)
Antibody Application Notes: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Flow cytometry: 0.5-1 ug/million cells/Immunofluorescence: 0.5-1 ug/mL/Optimal dilution for a specific application should be determined by user
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