CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) (CFTR/2290R), CF740 conjugate, 0.1mg/mL

CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) (CFTR/2290R), CF740 conjugate, 0.1mg/mL
SKU
BTMBNC742290-100
Packaging Unit
100 uL
Manufacturer
Biotium

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Description: This antibody recognizes a protein of 165-170 kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Origin: Animal - Oryctolagus cuniculus (domestic rabbit), Bos taurus (bovine)

Conjugate: CF740

Concentration: 0.1 mg/mL

Storage buffer: PBS, 0.1% rBSA, 0.05% azide

Clone: CFTR/2290R

Immunogen: Recombinant full-length human CFTR protein

Antibody Reactivity: CFTR

Entrez Gene ID: 1080

Z-Antibody Applications: IHC, FFPE (verified)

Verified AB Applications: IHC (FFPE) (verified)

Antibody Application Notes: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Immunohistology (formalin): 0.5-1.0 ug/mL for 30 minutes at RT/Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA pH 9.0 for 10-20 minutes followed by cooling at RT for 20 minutes/Optimal dilution for a specific application should be determined by user
More Information
SKU BTMBNC742290-100
Manufacturer Biotium
Manufacturer SKU BNC742290-100
Package Unit 100 uL
Quantity Unit STK
Reactivity Human, Mouse (Murine)
Clonality Recombinant
Application Immunohistochemistry
Isotype IgG
Host Rabbit
Conjugate Conjugated, CF740
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