CM699 (hydrochloride)

Shelf life (days): 1460

Info: A dual σ receptor antagonist (Kis = 0.0141 and 0.00231 µM for the σ1 and σ2 receptors, respectively) and DAT inhibitor (Ki = 0.311 µM); selective for the σ1 and σ2 receptors and DAT over SERT (Ki = 2.83 µM) but also binds to NET (Ki = 0.232 µM); inhibits dopamine uptake in rat striatal synaptosomes (IC50 = 6.01 µM) and induces σ1 receptor multimerization, indicating antagonist activity, in HEK293 cells expressing the human receptor at 20 µM; decreases self-administration of cocaine in rats

Formulation: A neat solid

Formal Name: 1,3-dihydro-1-methyl-3-[4-(spiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl)butyl]-2H-benzimidazol-2-one, monohydrochloride

Purity: ≥98%

Formula Markup: C24H29N3O2 • HCl

Formula Weight: 427.973

• SKU: CAY43519-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 43519-5
• Package Unit: 5 mg
• Quantity Unit: STK