Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-[[4-ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid
Purity: ≥98%
Formula Markup: C25H23N3O4S
Formula Weight: 461.5
CAS Number: 913827-99-3
Notes: CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist.{51894,51893} It selectively induces GTPγS binding in CHO-K1 cells expressing human or rat S1P1 (EC50s = 4 and 1.5 nM, respectively) over those expressing human or rat S1P3 (EC50s = >20 and 7.4 µM, respectively).{51894} CS 2100 (0.1 and 1 mg/kg) transiently reduces blood lymphocyte levels in rats with the levels returning to baseline within 24-48 hours. It reduces hind paw volume in a rat model of adjuvant-induced arthritis (ID50 = 0.44 mg/kg). CS 2100 (0.3 and 1 mg/kg) also decreases severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).
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