CSN5-IN-2

Product Description: CSN5-IN-2 (Compound 31) is a CSN5 inhibitor with an IC50 of 0.36 μM. CSN5-IN-2 can increase the level of Cullin 1 neddylation, and downregulate the expression of RAD51 and PD-L1 in cancer cells. CSN5-IN-2 has anti-tumor activity, and its effect is better when combined with Talazoparib (HY-16106)[1].

Formula: C32H38N6O2

References: [1]Lei P, et al. Discovery of New Azaindole Metallo-Deubiquitinase CSN5 Inhibitors. J Med Chem. 2025 Mar 27;68(6):6748-6765.

Molecular Weight: 538.68

Research Area: Cancer

Target: PD-1/PD-L1;RAD51

• SKU: MEXHY-172252-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-172252-0
• Package Unit: Get quote
• Quantity Unit: STK