Shelf life (days): 730.0
Formulation: A solution in chloroform
Formal Name: (5R,6R)-rel-6-ethenyl-4,5,6,7-tetrahydro-3,6-dimethyl-5-(1-methylethenyl)-benzofuran
Purity: ≥95%
Formula Markup: C15H20O
Formula Weight: 216.3
CAS Number: 17910-09-7
Notes: Curzerene is a sesquiterpene that has been found in C. longa and has diverse biological activities.{69907,60438,69908,69909} It scavenges DPPH (Item No. 14805) radicals in a cell-free assay when used at a concentration of 3.36 µg/L with a synergistic effect when used in combination with the bicyclic monoterpene eucalyptol (Item No. 22183).{69908} Curzerene (0.5 mg/ml) is active against F. graminearum.{60438} It inhibits the proliferation of SK-MEL-19 melanoma cells (IC50 = 5.17 µg/ml), as well as AGP-01 gastric and HCT116 colon cancer cells (IC50s = 8.04 and 9.18 µg/ml, respectively) and MRC-5 non-cancerous fibroblasts (IC50 = 11.45 µg/ml).{69907} It also induces apoptosis in, and decreases migration of, SK-MEL-19 cells when used at concentrations of 5 and 10 µM. Curzerene (135 mg/kg) reduces tumor weight in an SPC-A1 lung adenocarcinoma mouse xenograft model.{69909}