Cyclotraxin B, CAS 1203586-72-4

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: cyclic (1?11)-disulfide L-cysteinyl-L-asparaginyl-L-prolyl-L-methionylglycyl-L-tyrosyl-L-threonyl-L-lysyl-L-a-glutamylglycyl-L-cysteine

Purity: ≥98%

Formula Markup: C48H73N13O17S3

Formula Weight: 1200.366

CAS Number: 1203586-72-4

Notes: A cyclic peptide and negative allosteric modulator of TrkB; inhibits BDNF-induced TrkB activity in a KIRA-ELISA using TetOn-rhTrkB cells (IC50 = 0.3 nM); inhibits BDNF-induced neurite outgrowth nnr5 PC12-TrkB cells (IC50 = 12.2 pM); reduces mechanical, but not thermal, allodynia in the ipsilateral and contralateral paw in a rat model of thermal injury exacerbated by chronic intermittent stress at 20 mg/kg per day; intravenous administration of cyclotraxin B fused to HIV-1 Tat protein induces anxiolytic-like activity in mice

• SKU: CAY42991-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42991-5
• Package Unit: 5 mg
• Quantity Unit: STK