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Background: Trophoblast cell-surface antigen 2 (TROP-2, also known as tumor associated calcium signal transducer 2, TACSTD2, GA733-1 or M1S1), is a cell surface glycoprotein that is highly expressed in a variety of solid cancers compared to normal cells. Through a variety of signaling pathways, TROP2 regulates cancer growth and metastasis and is a candidate target for antibody drug conjugates (ADC) and immunotherapy.
CAS Number: 2238831-60-0
Description: Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity.1
Format: Aqueous buffer solution.
Purity: ≥90%
Storage Stability: Store at -80°C, protect from light.
Target: TROP2
Uniprot: P09758
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Daisuke Okajima, et al., 2021 Mol Cancer Ther. 20(12):2329-2340.
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