DBPR108, CAS 1186426-66-3

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 1-[2S-[[1,1-dimethyl-3-oxo-3-(1-pyrrolidinyl)propyl]amino]acetyl]-4S-fluoro-2-pyrrolidinecarbonitrile

Purity: ≥98%

Formula Markup: C16H25FN4O2

Formula Weight: 324.4

CAS Number: 1186426-66-3

Notes: DBPR108 is an inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 0.015 µM).{51855} It is selective for DPP-4 over DPP-8 and DPP-9 (IC50s = >50 µM for both). DBPR108 (10 mg/kg) increases plasma levels of glucagon-like peptide 1 (GLP-1) and insulin in rats.{51856} It reduces blood glucose levels in an oral glucose tolerance test in mice when administered at a dose of 3 mg/kg.{51855} DBPR108 (0.1 mg/kg), alone and in combination with the biguanide metformin (Item No. 13118), decreases blood glucose levels in an oral glucose tolerance test in a mouse model of high-fat diet-induced obesity.{51856}

• SKU: CAY41117-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41117-5
• Package Unit: 5 mg
• Quantity Unit: STK