Shelf life (days): 365.0
Formulation: Lyophilized from sterile 50 mM Tris, 500 mM sodium chloride
Uniprot ID: Q5XX08
Purity: ≥95% estimated by SDS-PAGE
Formula Weight: 0.0
Notes: Ebola virus (EBOV) is an enveloped and negative-stranded RNA virus, a member of the Ebolavirus genus, and the causative agent of Ebola virus disease (EVD), a condition characterized by a hemorrhagic fever and a high mortality rate, that is endemic to western and equatorial Africa.{69796} The single-stranded RNA genome of EBOV encodes seven proteins: nucleoprotein (NP), virion protein 40 (VP40), VP35, VP30, VP24, glycoprotein (GP), and an RNA-dependent RNA polymerase (L).{69796,69797} Ebola virus NP is a 739-amino acid protein composed of an N-terminal domain, which is required for protein oligomerization and RNA binding, linked by an unstructured region to a C-terminal domain that functions as a protein-protein interaction hub and forms the viral nucleocapsid that encapsulates the RNA genome throughout the virus life cycle.{68804},{68805} This NP nucleocapsid is a protein-RNA complex acts as a scaffold for additional viral proteins, including L, the viral polymerase, to complete viral replication.{68805} Additionally, the Ebola virus NP is essential to viral genome replication, transcription, and maintenance of viral structure and protects the viral genome from host nucleases.{68804} Cayman's Ebola Virus Nucleoprotein (subtype Sudan, Strain Gulu) (recombinant; aa 630-738) consists of 108 amino acids and has a calculated molecular weight of 14.8 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is ~18.4 kDa.
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