Notes: Elsiglutide is a peptide derivative of glucagon-like peptide 2 (GLP-2).{68866} It increases jejunum and ileum crypt depth and villus height without disrupting gut microbiota diversity in rats when administered at a dose of 0.9 mg/kg four days per week. Elsiglutide decreases diarrhea severity and incidence induced by the dual inhibitor of EGFR and HER2 lapatinib (Item No. 11493) in rats. It prevents lapatinib-induced loss of body weight in rats.