Background: This antibody may be used to identify fibronectin during wound healing, during tumour progression, and tumour invasion respectively. Fibronectins are glycoproteins, which occur as dimers of two 200 kDa subunits. They have binding domains for bacterial proteins, collagens, heparin-like molecules and fibrin. Cellular fibronectin is widely distributed in the stroma of malignant tumours. Bovine fibronectin 100%, bovine collagen type I and III <0.1% (RIA at 1:10000 dilution).
Positive Control: Bovine skin or liver.
Immunogen: Purified fibronectin from bovine plasma.
Purification Method: Affinity purified antibody lyophilized from phosphate buffered solution (non-sterile). Contains antimycotic substance, but no BSA and sodium azide! Reconstitute with 0.5 ml of sterile water and store aliquots at -20°C. For further dilution use appropriate antibody diluent, e.g. Art. No. PU002 for IHC.
Concentration: app. 1 mg/ml.
References: 1. Ocampo Lyra J.S.P., Madi K., Maeda C.T., Savino W. (1993) Thymic extracellular matrix in human malnutrition. J. Pathol. 1993, 171, 231-236.
UniProt: P07589 (FINC_BOVIN).
Caution: *These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.
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