FKBP12 PROTAC FM4

Product Description: FKBP12 PROTAC FM4 is a PROTAC degrader of MTH1, with a DC50 values of 0.09–0.22 nM. FKBP12 PROTAC FM4 is composed of PROTAC target protein ligand AP1867-3-(aminoethoxy) (HY-129363) (red part), E3 ligase ligand MTH1 ligand 1 (HY-134724) (blue part) and PROTAC Linker t-Boc-N-amido-PEG5-acetic acid (HY-W190962) (black part), among which the conjugate of PROTAC target protein ligand + Linker is FKBP12 Ligand-Linker Conjugate 2 (HY-172266)[1].

Applications: Cancer-programmed cell death

Formula: C73H89N7O17

References: [1]Kyle Mangano, et al. VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation. Cell Chem Biol. 2025 Mar 20;32(3):423-433.e9.

Molecular Weight: 1336.52

Research Area: Cancer

Target: PROTACs

• SKU: MEXHY-172265-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-172265-0
• Package Unit: Get quote
• Quantity Unit: STK